• Random mating populations
• Hardy- Weinberg (H-W ) principle. Testing H-W proportions
• Estimation of allele frequencies. Sex-linked loci. Extensions and generalizations of HWE
• Deviations from H-W equilibrium
• Inbreeding coefficient (F). Inbreeding depression
• Estimation of F from pedigree analysis
• Genetic drift. Genetic drift and expected allele frequencies
• Patterns of genetic drift in the Wright- Fisher model
• Effect of population size in the Wright – Fisher model. Founder effect
• Effective population size. Unequal sex ratio. Fluctuating population size
• Mutation. Selectively neutral mutations. Harmful mutations. Advantageous mutations
• Population subdivision.F- Statistics
• Genetic divergence among populations and gene flow
• Linkage Disequilibrium (LD). LD coefficients. Change in LD due to random mating
• Wahlund effect
• Natural selection. Fitness. Single locus with two alleles. Multiple alleles
• Calculation of allele frequency changes
• Special cases of selection. Heterozygote advantage
• Mutation –selection balance. Genetic hitchhiking. Selective sweeps
• The neutral theory and tests of neutrality
Population Genetics, Matthew Hamilton 2009, Wiley-Blackwell
