1. Review of the concepts of Genetics and Epigenetics. Historical review of Epigenetics.
Enzymes of epigenetic action. Epigenetic mechanisms in animal cells.
2. Heredity in Epigenetics. Transfer of epigenetic modifications to gametes and genetic
improvement of animals. Examples of epigenetic differentiation on monozygotic
twins.
3. Inheritance and epigenetic mechanisms of polymorphic locations and gene
haplotypes. Inheritance of genetic alterations in the functionality of epigenetic
enzymes and their consequences.
4. Transgenerational epigenetic inheritance. The role of lifestyle, diet and metabolism in
epigenetic inheritance. Interactions of the metabolomic and epigenomic profile in
mammalian cells.
5. Epigenetic modulations in maintaining homeostasis in hematopoiesis and
myogenesis.
6. Epigenetic toxicology in agrobiotechnology.
7. Inheritance of epigenetic mechanisms of imprinting in Beckwith & Weidemann,
Prader-Willi and Angelman syndromes.
8. Epigenetic pathophysiology of diseases and new therapeutic approaches in diseases
such as, eating disorders, metabolism, immunological diseases, Alzheimer's, asthma,
heart disease, aging.
9. Epigenetics of cancer.
10. Abnormality of epigenetic programming and epigenetic changes in cloned animals
and assisted reproductive technologies (ART) in humans. Epigenetic signature of the
induced pluripotent stem cells, iPSCs.
11. Prions and epigenetics. Protein misfolding.
12. Recent developments in epigenetic research. Methods and experimental approaches
in Epigenetic analysis
