I. GENERAL PRINCIPLES
1. Structural elements of biomolecules (amino acids, bases, additive biomolecules, proteins,
nuclear acids).
2. Types of interactions involved in recognition (qualitative and quantitative analysis).
a. Interactions between individual atoms.
b. Interactions of structural elements of molecules.
3. Energy interaction analysis.
a. Molecular Engineering
b. Molecular Dynamics.
4. Recognition levels, high fidelity recognition.
a. Definition of Molecular Recognition.
b. The contribution of individual interactions to recognition.
j. Hydrogen bonds.
ii. Electrostatic interactions.
iii. Stereotypical obstruction.
c. General internal stabilization methodology. electric cargo.
5. Protein recognition areas.
a. Grades of recognition, high fidelity recognition.
b. Size and complexity of areas of recognition.
c. Structural elements
d. The position of the substrate.
6. Size and complexity of recognition areas.
II. CHEMICAL TRANSFER TRANSPORTATION AND INTERVENTION OF CELLS
1. Common molecular mechanisms for signal transduction.
a. Mechanisms
b. Active groups.
2. Hormones, neurotransmitters, local chemical mediators.
3. Signal transmission to membranes and cytoplasm.
4. Steroid hormones and their receptors. Pheromones
5. Structure of membrane proteins. Channels and receivers.
III. APPLICATIONS IN BIOTECHNOLOGY
1. Rational drug design.
2. Creation of antibodies against viruses and bacteria.
3. Insecticides-Pesticides. Biochemical processes.
4. Explain important plant processes at the molecular level.
a. Movement of ions in plants.
b. Photosynthesis.
c. The movement in the plants.
5. Antibody design against virii and bacteria.
6. Steroid hormones and their receptors.
IV. LABORATORY: Amino acids and protein stereotypes. Molecular identification of nuclear
acids. Membrane proteins. Hemoglobin. Proteolytic enzymes - Molecular action. Substrate
design. The molecular action of insecticides.
Introduction to Protein Structure (Branden & Tooze) (1991). Garland Publishing Inc, ISBN 0-8153-0270-3
Βιοχημεία Βασικές Αρχές (Stryer) Ελληνική Μετάφραση (2015) Broken Hill Publishers.
Communication within Animal Cells Greg J.Baritt , Oxford Science Pubs.1992 ISBN 0-19-854726-9
Plant Biochemistry and Molecular Biology Hans-Walter Heldt, Oxford Pubs. 1997 ISBN 0-19-850179-X
Molecular Plant Development Peter Westhoff , Oxford Pubs. 1998 ISBN 0-19-850203-6
Proteins: Form and Function (Bradshaw & Purton Eds.) (1990). Elsevier Trends Books ISBN 1 85166 512 9
BioEnergetics (Albert Lehninger) (1973).
The Benjamin/Cummings Publishing Company ISBN 0-8053-6103-0
Chemical Communication: The Language of Pheromones (Agosta) (1992)
